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US development "category organs" New technology can "build" a model of human tissue


University of California, San Francisco (UCSF) research team developed a "class organ" (Organoid) manufactured by new technology, can human cells as a biological "building blocks" to build a more accurate model of human tissue microarrays. These tiny tissue can be used for drug screening, structural characteristics of tissue and organ growth or cancer of, but also help cultivate a future full of human organs.

According to physicist organization network August 31 reported that the "class organ" technique is also called "DNA programmed cell assembly" (DPAC), allows researchers to design and manufacture an array of thousands of types of organ cells, for example, just a few hours can be made out of human breast model.

Paper's senior author, UCSF associate professor of medicinal chemistry · 伽特纳 Chak Ng said: "We can be programmed using a variety of cells, so that they grow directional control 'dialogue' and activities between the cells contact each other to comply with the initial programming of these cells to develop. The trajectory of interaction, four extensions, gradually develop into tissue. "

The researchers published in the "natural method" magazine published 31 papers called for qualified class organ 3D structure, they are familiar with the use of DNA molecules and the small piece of single-stranded DNA is inserted in each of the cell membrane, both as A molecular buckle, but also a "bar code" that specifies the location of each cell in the organ in the class. After two cell growth with complementary DNA strands contact will soon buckle together. If the DNA sequence does not match, the cells will continue to float. Cells can also be used with a plurality of sets of DNA "partner" is connected.

Jia Tena team gave several sets of cells connected special "partner", the cell barrier layers together, not only to create a complex organization such as the breast, but also the cancerous cells were added to different parts of the class organs experiment with observed effect.

Team graduate Michael Todd Hunter said: "This technology allows us to create a simple organizational model in a Petri dish, without doing experiments in humans, we can explore the complexity of the problem of human tissue."

"In the future, we will collect samples of breast cancer patients with different parts of the organization to make their own model, as individualized drug screening platform." 伽特纳 said, the future is expected to use the technology to produce functional human tissue, such as lung, kidney, nerve lines.

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